![]() Then they embedded it in resin to toughen it. ![]() Lichtman and his team immediately immersed the sample in preservatives, then stained it with heavy metals like osmium, so the outer membranes of every cell were visible under an electron microscope. To do this, the surgeons had to remove some healthy brain tissue that overlaid the hippocampus. She underwent surgery to remove the left hippocampus, the source of her seizures, from her brain. This mammoth undertaking began when a team lead by Jeff Lichtman, also at Harvard University, obtained a tiny piece of brain from a 45-year-old woman with drug-resistant epilepsy. “There’s something just a little emotional about it.” It is the first time we have seen the real structure of such a large piece of the human brain, says Catherine Dulac at Harvard University, who wasn’t involved in the work.
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